What's the best martial art/fighting style for fighting much larger opponents?

I have practiced Tae Kwon Do, Kickboxing and wrestling on and off for about 25 years now. While I feel confident in fighting someone that is about my same size, I would be very hesitant to fight someone significantly larger than me. Does anyone have any opinions about what styles of fighting are better for fighting opponents that are 50 to 100 lbs heavier than you?